Division of Metabolism, Diabetes, and Endocrinology (R.J.A., E.O.B., G.D.H., C.R., D.M.), University of Michigan, Ann Arbor, Michigan 48109; Division of Endocrinology, Metabolism, Diabetes, and Nutrition (A.Y.C.), Mayo Clinic, Rochester, Minnesota 55905; Janssen Research and Development (G.W., M.G., X.S.X., J.J.), Raritan, New Jersey 08869; Janssen Research and Development (J.W.S.), 2340 Beerse, Belgium; and Janssen Research and Development (M.K.Y.), Los Angeles, California 90024.